Treatments for chordoma

Last medical review:

The following are treatment options for chordoma. Your healthcare team will suggest treatments based on your needs and work with you to make a treatment plan.

Surgery

Surgery is the standard treatment for chordoma. The following types of surgery may be used.

Wide resection

Wide resection removes the bone tumour and a small amount of tissue and bone around it (called a surgical margin). Doctors may use other terms for wide resection, such as en bloc resection or wide excision. Wide resection is the main surgical method used to treat chordoma.

Curettage

Curettage is a procedure that uses a spoon-shaped tool with a sharp edge (called a curette) to scrape a tumour out of the bone. This leaves a hole where the tumour was removed. After curettage, the surgeon may use bone cement to fix the hole left in the bone and destroy any remaining cancer cells. Bone cement is a chemical called polymethyl methacrylate. This special cement heats up as it hardens, so it can kill any remaining cancer cells in the bone. Curettage may be used in an area where a wide resection can’t be done safely, like in the skull or spine.

Find out more about surgery for bone cancer.

Radiation therapy

Radiation therapy uses high-energy rays or particles to destroy cancer cells. You may be offered radiation therapy for chordoma.

External radiation therapy may be used to:

  • destroy any cancer cells left behind after a wide resection or curettage
  • treat chordomas that can’t be removed with surgery.

Find out more about radiation therapy for bone cancer.

Chemotherapy

Chemotherapy uses drugs to destroy cancer cells. It is usually offered for advanced chordoma that has spread (metastasized) and can’t be removed with surgery.

The most common chemotherapy drugs used to treat chordoma are:

  • imatinib
  • doxorubicin

The most common chemotherapy drug combinations used to treat chordoma are:

  • imatinib and cisplatin
  • CISPDOXO – doxorubicin and cisplatin

Find out more about chemotherapy for bone cancer.

Clinical trials

Talk to your doctor about clinical trials open to people with bone cancer in Canada. Clinical trials look at new ways to prevent, find and treat cancer. Find out more about clinical trials.

Expert review and references

  • Michael Monument, MD, MSc, FRCSC
  • Kim Tsoi, BASc, MD, PhD, FRCSC
  • Strauss SJ, Frezza AM, Abecassis N, et al. Bone sarcomas: ESMO–EURACAN–GENTURIS–ERN PaedCan Clincial Practice Guideline for diagnosis, treatment and follow-up. Annals of Oncology. 2021: 32(12):1520–1536.
  • American Cancer Society. Bone Cancer. 2021. https://www.cancer.org/.
  • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Bone Cancer Version 2.2024. 2024.
  • O'Donnell RJ, DuBrois SG, Haas-Kogan DA, Braunstein SE, Hameed M. Sarcomas of Bone. DeVita VT Jr, Lawrence TS, Rosenberg S. eds. DeVita Hellman and Rosenberg's Cancer: Principles and Practice of Oncology. 12th ed. Philadelphia, PA: Wolters Kluwer; 2023: Kindle version, chapter 61, https://read.amazon.ca/?asin=B0BG3DPT4Q&language=en-CA.
  • Samuel LC. Bone and soft tissue sarcomas. Yarbro CH, Wujcik D, Gobel B (eds.). Cancer Nursing: Principles and Practice. 8th ed. Burlington, MA: Jone & Bartlett Learning; 2018: Kindle version, chapter 46, https://read.amazon.ca/?asin=B01M6ZZEWT&ref_=kwl_kr_iv_rec_1.

Your trusted source for accurate cancer information

With just $5 from readers like you, we can continue to provide the highest quality cancer information for over 100 types of cancer.

We’re here to ensure easy access to accurate cancer information for you and the millions of people who visit this website every year. But we can’t do it alone.

If everyone reading this gave just $5, we could achieve our goal this month to fund reliable cancer information, compassionate support services and the most promising research. Please give today because every contribution counts. Thank you.

Medical disclaimer

The information that the Canadian Cancer Society provides does not replace your relationship with your doctor. The information is for your general use, so be sure to talk to a qualified healthcare professional before making medical decisions or if you have questions about your health.

We do our best to make sure that the information we provide is accurate and reliable but cannot guarantee that it is error-free or complete.

The Canadian Cancer Society is not responsible for the quality of the information or services provided by other organizations and mentioned on cancer.ca, nor do we endorse any service, product, treatment or therapy.


1-888-939-3333 | cancer.ca | © 2025 Canadian Cancer Society