Radiation therapy for bone cancer

Last medical review:

Radiation therapy uses high-energy rays or particles to destroy cancer cells.

Many people with bone cancer have radiation therapy. Your healthcare team will use what they know about the cancer and about your health to plan the type and amount of radiation, and when and how it is given.

You may have radiation therapy to:

  • shrink a tumour before surgery (called neoadjuvant therapy)
  • destroy cancer cells left behind after surgery to reduce the risk that the cancer will come back (called adjuvant therapy)
  • treat a bone tumour that can’t be removed with surgery (is unresectable)
  • relieve pain or control the symptoms of advanced bone cancer (called palliative therapy)

External radiation therapy is the type of radiation therapy used to treat bone cancer.

External radiation therapy

During external radiation therapy, a machine directs radiation through the skin to the tumour and some of the tissue around it. External radiation therapy is also called external beam radiation therapy.

Radiation therapy is usually given in small daily doses (called fractions) over a period of 4 to 5 weeks.

Doctors may use the following types of external radiation therapy to accurately target the area to be treated and spare as much surrounding normal tissue as possible.

Intensity-modulated radiation therapy (IMRT) delivers radiation from many different angles to treat the entire tumour. In addition to shaping and aiming the radiation beams, IMRT allows the radiation oncologist to adjust the strength (intensity) of the individual beams. This reduces the dose of radiation reaching nearby normal tissue while allowing a higher dose to be delivered to the tumour. IMRT can be useful for treating bone tumours in hard-to-reach areas like the skull, spine or pelvis.

Stereotactic radiosurgery gives very high doses of radiation to a very specific area where cancer is found. It is given in a small number of sessions. It may be used to treat bone cancer that has spread to the brain or the lungs. Stereotactic radiosurgery may be available in some hospitals in Canada.

Side effects

During radiation therapy, your healthcare team protects healthy cells in the treatment area as much as possible. Side effects of radiation therapy will depend mainly on the size of the area being treated, the specific area being treated, the total dose of radiation and the treatment schedule. Tell your healthcare team if you have these side effects or others you think might be from radiation therapy. The sooner you tell them of any problems, the sooner they can suggest ways to help you deal with them.

These are common side effects of radiation therapy for bone cancer:

Find out more about radiation therapy

Find out more about radiation therapy and side effects of radiation therapy. To make the decisions that are right for you, ask your healthcare team questions about radiation therapy.

Expert review and references

  • Michael Monument, MD, MSc, FRCSC
  • Kim Tsoi, BASc, MD, PhD, FRCSC
  • Strauss SJ, Frezza AM, Abecassis N, et al. Bone sarcomas: ESMO–EURACAN–GENTURIS–ERN PaedCan Clincial Practice Guideline for diagnosis, treatment and follow-up. Annals of Oncology. 2021: 32(12):1520–1536.
  • O'Donnell RJ, DuBrois SG, Haas-Kogan DA, Braunstein SE, Hameed M. Sarcomas of Bone. DeVita VT Jr, Lawrence TS, Rosenberg S. eds. DeVita Hellman and Rosenberg's Cancer: Principles and Practice of Oncology. 12th ed. Philadelphia, PA: Wolters Kluwer; 2023: Kindle version, chapter 61, https://read.amazon.ca/?asin=B0BG3DPT4Q&language=en-CA.
  • American Cancer Society. Bone Cancer. 2021. https://www.cancer.org/.
  • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Bone Cancer Version 2.2024. 2024.
  • Samuel LC. Bone and soft tissue sarcomas. Yarbro CH, Wujcik D, Gobel B (eds.). Cancer Nursing: Principles and Practice. 8th ed. Burlington, MA: Jone & Bartlett Learning; 2018: Kindle version, chapter 46, https://read.amazon.ca/?asin=B01M6ZZEWT&ref_=kwl_kr_iv_rec_1.

Your trusted source for accurate cancer information

With just $5 from readers like you, we can continue to provide the highest quality cancer information for over 100 types of cancer.

We’re here to ensure easy access to accurate cancer information for you and the millions of people who visit this website every year. But we can’t do it alone.

If everyone reading this gave just $5, we could achieve our goal this month to fund reliable cancer information, compassionate support services and the most promising research. Please give today because every contribution counts. Thank you.

Medical disclaimer

The information that the Canadian Cancer Society provides does not replace your relationship with your doctor. The information is for your general use, so be sure to talk to a qualified healthcare professional before making medical decisions or if you have questions about your health.

We do our best to make sure that the information we provide is accurate and reliable but cannot guarantee that it is error-free or complete.

The Canadian Cancer Society is not responsible for the quality of the information or services provided by other organizations and mentioned on cancer.ca, nor do we endorse any service, product, treatment or therapy.


1-888-939-3333 | cancer.ca | © 2025 Canadian Cancer Society