Risk factors for Hodgkin lymphoma

Last medical review:

Some things can affect your risk, or chance, of developing cancer. Certain behaviours, substances or conditions can increase or decrease the risk. Most cancers are the result of many risk factors. But sometimes cancer develops in people who don’t have any risks.

Most cases of Hodgkin lymphoma are diagnosed in adults between 20 and 40 years of age, though there is an increase in diagnosis in adults older than 50. It affects men slightly more often than women.

The following can increase your risk for Hodgkin lymphoma:

Epstein-Barr virus infection

Family history

HIV infection

Epstein-Barr virus infection

Infection with the Epstein-Barr virus (EBV) is a risk factor for Hodgkin lymphoma. EBV is a type of herpes virus that causes infectious mononucleosis (also called mono, or the kissing disease). Many people are infected with EBV, but only some of them develop a long-term infection.

Find out more about the Epstein-Barr virus.

Family history

First-degree relatives of a person with Hodgkin lymphoma, particularly siblings of the same sex, have a higher risk of developing the disease. It’s unclear if the higher risk is due to genetics alone or a combination of genetics and being exposed to similar factors in the environment.

HIV infection

The human immunodeficiency virus (HIV) is the virus that causes AIDS. HIV weakens the body’s immune system and may leave people vulnerable to certain types of cancer, including Hodgkin lymphoma.

Find out more about the human immunodeficiency virus (HIV).

Possible risk factors

The following have been linked with an increased risk of Hodgkin lymphoma, but more research is needed to know for sure that they are risk factors:

  • solid organ transplantation
  • infectious mononucleosis
  • autoimmune diseases, including rheumatoid arthritis and lupus
  • smoking tobacco
  • socioeconomic status

Understanding your cancer risk

To make the decisions that are right for you, ask your doctor questions about risks. Learn how cancer can be prevented and what you can do to reduce your risk.

Expert review and references

  • Canadian Cancer Society | Société canadienne du cancer
  • American Cancer Society. Hodgkin Lymphoma Causes, Risk Factors and Prevention. 2025. https://www.cancer.org/.
  • Buck CB, Ratner L, Tosato G. Oncogenic viruses. DeVita VT Jr., Lawrence TS, Rosenberg SA (eds.). DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. 11th ed. Philadelphia: Wolters Kluwer; 2019: 7:98-114.
  • Hjalgrim H, Chang ET, Glaser SL. Hodgkin lymphoma. Thun MJ (ed.). Schottenfeld and Fraumeni Cancer Epidemiology and Prevention. 4th ed. New York, NY: Oxford University Press; 2018: 39: 745 - 765.
  • International Agency for Research on Cancer (IARC). Volume 67: Human immunodeficiency viruses and human T-cell lymphotropic viruses. 1996.
  • International Agency for Research on Cancer (IARC). Volume 70: Epstein-Barr virus and Kaposi's sarcoma herpesvirus/human herpesvirus 8. 1997.
  • International Agency for Research on Cancer (IARC). Volume 100B: Biological agents: A Review of Human Carcinogens. 2012.
  • International Agency for Research on Cancer (IARC). IARC Monographs on the Idenification of Carcinogenic Hazards to Humans Volume 100D: Radiation: A Review of Human Carcinogens. 2011.
  • International Agency for Research on Cancer (IARC). IARC Monographs on the Idenification of Carcinogenic Hazards to Humans Volume 100E: Personal Habits and Indoor Combustions. 2012.
  • Jin F, Vajdic CM, Poynten M, McGee-Avila J, Castel PE, Grulich AE. Cancer risk in people living with HIV and solid organ transplant recipients - a systematic review and meta-analysis. Lancet Oncology. 2024: 25(7):933-944.

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