What is oral cancer?

Last medical review:

Oral cancer starts in the cells of the mouth. A cancerous (malignant) tumour is a group of cancer cells that can grow into nearby tissue and destroy it. The tumour can also spread (metastasize) to other parts of the body. Oral cancer may also be called oral cavity cancer or mouth cancer.

Cells in the mouth sometimes change and no longer grow or behave normally. These changes may lead to non-cancerous (benign) conditions such as warts, fibromas, canker sores and cold sores.

Changes to cells of the mouth can also cause precancerous conditions. This means that the abnormal cells are not yet cancer, but there is a chance that they will become cancer if they aren't treated. The most common precancerous condition of the mouth is oral epithelial dysplasia.

But in some cases, changes to the cells of the mouth can cause oral cancer. Most often, oral cancer starts in thin, flat cells called squamous cells. These cells make up the mucous membrane that lines the mouth (the oral mucosa). This type of cancer is called squamous cell carcinoma (SCC) of the mouth.

Rare types of oral cancer can also develop. These include salivary gland cancer, melanoma and soft tissue sarcoma.

Expert review and references

  • Patricia Brooks, HBSc, MSc, DDS, FRCD(C), Dip ABOMP, PhD
  • Mark Taylor, MD, FRCSC
  • Dziegielewski PT, Mendenhall WM, Dunn LA. Cancer of the Oral Cavity. DeVita VT Jr, Lawrence TS, Rosenberg S. eds. DeVita Hellman and Rosenberg's Cancer: Principles and Practice of Oncology. 12th ed. Philadelphia, PA: Wolters Kluwer; 2023: Kindle version, [chapter 27], https://read.amazon.ca/?asin=B0BG3DPT4Q&language=en-CA.
  • Hashibe M, Strugis EM, Ferlay J, Winn DM. Oral Cavity, Oropharynx, Lip, and Salivary Glands. Thun MJ, Linet MS, Cerhan JR, Haiman CA, Schottenfeld D, eds.. Schottenfeld and Fraumeni Cancer Epidemiology and Prevention . 4th ed. New York, NY: Oxford University Press; 2018: Kindle version, [chapter 29] https://read.amazon.ca/?asin=B0777JYQQC&language=en-CA.
  • Machiels JP, Leemans CR, Golusinski W, Grau C, Licitra L, Gregoire V. Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS–ESMO–ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2020: 31(11):1462–1475.
  • Tuluc M, Bar-Ad V, Cognetti D, Johnson J, Axelrod R. Uncommon Tumors of the Oral Cavity and Adjacent Structures. Raghavan D, Ahluwalia MS, Blanke CD, et al, eds.. Textbook of Uncommon Cancer . 5th ed. Hoboken, NJ: Wiley Blackwell; 2017: Kindle version, [chapter 10], https://read.amazon.ca/?asin=B0BG3DPT4Q&language=en-CA.

The mouth

Oral cancer starts in the mouth (oral cavity). The mouth is part of the digestive system.

Cancerous tumours of the mouth

Squamous cell carcinoma is the most common type of cancerous tumour of the mouth. There are also rare types of tumours of the mouth.

Precancerous conditions of the mouth

Precancerous conditions of the mouth are changes to cells that make them more likely to develop into cancer.

Non-cancerous conditions of the mouth

Warts, fibromas, canker sores and cold sores are the most common non-cancerous conditions of the mouth.

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