Prognosis and survival for parathyroid cancer

Last medical review:

A prognosis is the doctor’s best estimate of how cancer will affect you and how it will respond to treatment. Survival is the percentage of people with a disease who are alive at some point in time after their diagnosis. Prognosis and survival depend on many factors.

The doctor will look at certain aspects of the cancer as well as characteristics of the person. These are called prognostic factors. The doctor will also look at predictive factors, which influence how a cancer will respond to a certain treatment and how likely it is that the cancer will come back after treatment.

Prognostic and predictive factors are often discussed together. They both play a part in deciding on a prognosis and a treatment plan just for you. Only a doctor familiar with your medical history, whether and where the cancer has spread, the treatments chosen and the response to treatment can put all of this information together with survival statistics to arrive at a prognosis and chances of survival.

The following are prognostic and predictive factors for parathyroid cancer.

Distant metastasis

Parathyroid cancer has a poorer prognosis when it spreads another part of the body (called distant metastasis), such as the lung, the liver or the bones.

Surgical margin

The surgical margin is the healthy tissue surrounding a tumour that is removed along with the tumour during surgery. After surgery, the tissue that was removed is sent to a lab. A pathologist looks at a sample of the tissue under a microscope to see if there are cancer cells in the surgical margin.

A negative surgical margin means that there are no cancer cells at the edges of the tissue removed during surgery. A positive surgical margin means that cancer cells are found at the edges.

Parathyroid cancer that is completely removed (has a negative surgical margin) has a better prognosis than parathyroid cancer that is not completely removed.

Expert review and references

  • Jesse Pasternak, MD, MPH, FRCSC
  • PDQ Adult Treatment Editorial Board. Parathyroid Cancer Treatment (PDQ®)–Health Professional Version. Bethesda, MD: National Cancer Institute; 2024. https://www.cancer.gov/.
  • Hadoux J, Lamarca A, Grande E, Baudin E and Berruti A. Neuroendocrine neoplasms of head and neck, genitourinary and gynaecological systems, unknown primaries, parathyroid carcinomas and intrathyroid thymic neoplasms: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. ESMO Open. 2024: 6(10):103664.
  • Landry CS, Wang TS, Asare EA, et al.. Parathyroid. Amin, MB (ed.). AJCC Cancer Staging Manual [use individual chapters use citation title and author]. 8th ed. Chicago, IL: American College of Surgeons; 2017: 75:911—918.
  • Ullah A, Khan J, Waheed A, Sharma N, Pryor E, et al.. Parathyroid Carcinoma: Incidence, Survival Analysis, and Management: A Study from the SEER Database and Insights into Future Therapeutic Perspectives. Cancers. 2022: 14(6):1426.

Survival statistics for parathyroid cancer

Survival statistics for parathyroid cancer are very general estimates. Talk to your doctor about the statistics and what they mean for you.

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