Signs and symptoms of mesothelioma

Last medical review:

Mesothelioma may not cause any signs or symptoms in its early stages. It can cause fluid to build up around the lungs (called pleural effusion) or in the abdomen (called ascites), which can cause symptoms. Other signs and symptoms often appear once the tumour grows into surrounding tissues and organs. Because mesothelioma doesn’t cause signs or symptoms in its early stages, it is usually diagnosed after it has spread (metastasized) to other parts of the body.

Exposure to asbestos is the most important risk for mesothelioma. But it can take 20 to 60 years after coming into contact with asbestos before signs and symptoms of mesothelioma develop. So it is important to know and watch for the symptoms of mesothelioma if you have been exposed to asbestos.

The signs and symptoms of mesothelioma can vary depending on if the cancer starts in the pleura or peritoneum. Other health conditions can also cause the same symptoms as mesothelioma.

Pleural mesothelioma

Pleural mesothelioma starts in the membrane that lines the chest wall and covers each of the lungs (called the pleura). The most common sign of pleural mesothelioma is shortness of breath (dyspnea). This may be caused by fluid buildup on the lungs (pleural effusion).

Other signs and symptoms of pleural mesothelioma include:

  • aching or pain in the chest or lower back
  • dry cough
  • fatigue
  • weight loss
  • fever
  • heavy sweating, especially at night
  • swallowing problems or feeling like food is getting stuck in the throat
  • swelling of the face and arms
  • hoarseness

Peritoneal mesothelioma

Peritoneal mesothelioma starts in the membrane that lines the abdominal wall and covers and supports organs in the abdomen (called the peritoneum). The signs and symptoms of peritoneal mesothelioma include:

Symptoms that need urgent treatment

In some cases, mesothelioma or its treatment can cause serious problems. These cancer-related emergencies need to be treated right away:

Expert review and references

  • John Cho, MD, PhD, FRCPC
  • American Cancer Society. Malignant Mesothelioma. 2018. https://www.cancer.org/.
  • Pass H, Carbone M, Tsao A, Rosenzweig Z. Benign and Malignant Mesothelioma. DeVita VT Jr, Lawrence TS, Rosenberg S. eds. DeVita Hellman and Rosenberg's Cancer: Principles and Practice of Oncology. 12th ed. Philadelphia, PA: Wolters Kluwer; 2023: Kindle version, [chapter 76], https://read.amazon.ca/?asin=B0BG3DPT4Q&language=en-CA.
  • National Comprehensive Cancer Network. NCCN Guidelines for Patients: Pleural Mesothelioma. 2022.
  • Nowak AK, Edwards JG, Creaney J. Mesothelioma. Raghavan D, Ahluwalia MS, Blanke CD, et al, eds.. Textbook of Uncommon Cancer. 5th ed. Hoboken, NJ: Wiley Blackwell; 2017: Kindle version (chapter 16) https://read.amazon.ca/?asin=B06XKD44V3&_encoding=UTF8&ref=dbs_p_ebk_r00_pbcb_rnvc00.

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