Precancerous conditions of the larynx

Last medical review:

Precancerous conditions of the larynx are changes to laryngeal cells that make them more likely to develop into cancer. These conditions are not yet cancer. But if they arenʼt treated, there is a chance that these changes will become laryngeal cancer.

The most common precancerous condition of the larynx is dysplasia. Dysplasia means that cells look different from normal cells in size, shape and organization within the tissue.

The World Health Organization (WHO) categorizes dysplasia into either low grade or high grade.

Low-grade dysplasia means that some of the cells within the tissue look abnormal. These cells may look like cancer cells.

High-grade dysplasia means that some of the cells within the tissue look very abnormal. There is a higher chance that high-grade dysplasia turns into a very early stage of cancer called carcinoma in situ (stage 0). Carcinoma in situ is localized, meaning it has not yet spread to surrounding tissues.

Risk factors

The following risk factors increase your chance of developing dysplasia:

  • smoking tobacco
  • drinking alcohol

Symptoms

The symptoms of dysplasia include:

  • a hoarse voice
  • a weak voice or voice that tires easily

Diagnosis

If you have symptoms or your doctor thinks you might have dysplasia, you will be sent for tests. Tests used to diagnose dysplasia include:

Treatments

Treatment options for dysplasia include:

Expert review and references

  • Harold Lau, MD, FRCPC

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