What is vulvar cancer?

Last medical review:

Vulvar cancer starts in the cells of the vulva. A cancerous (malignant) tumour is a group of cancer cells that can grow into nearby tissue and destroy it. The cancer cells can also spread (metastasize) to other parts of the body.

The vulva forms the outer part of the female reproductive system. It includes the clitoris, labia and other external, visible sex organs that surround the vaginal opening.

Cells in the vulva sometimes change and no longer grow or behave normally. These changes may lead to non-cancerous (benign) conditions such as Bartholin gland cyst or lichen sclerosus. They can also lead to non-cancerous tumours such as fibromas.

Changes to cells of the vulva can also cause precancerous conditions. This means that the abnormal cells are not yet cancer, but there is a chance that they will become cancer if they aren’t treated. The most common precancerous condition of the vulva is vulvar intraepithelial neoplasia (VIN).

But in some cases, changes to vulvar cells can cause vulvar cancer. Most often, vulvar cancer starts in flat, thin cells called squamous cells. These cells are the main type of skin cells. This type of cancer is called squamous cell carcinoma (SCC) of the vulva. Vulvar cancer can also start in melanocytes, which are skin cells that make pigments. Cancer that starts in melanocytes in the vulva is called vulvar melanoma.

Other types of vulvar cancer can also develop. These include Paget disease of the vulva, sarcoma and basal cell carcinoma.

Expert review and references

  • Alon Altman, H.BSc., MD, FRCSC, CCPE
  • American Cancer Society. What is Vulvar Cancer. 2018. https://www.cancer.org/.
  • Cancer Research UK. What is Vulval Cancer. 2022. https://www.cancerresearchuk.org/.
  • Capria A, Tahir N, Fatehi M. Vulvar cancer. StatPearls [Internet]. StatPearls Publishing; 2023. https://www.statpearls.com/.
  • Ling DC, Beriwal S. Vulvar cancer: etiology, risk factors, genetics, and molecular biology. Chi DS, Khabele D, Dizon DS, Yasha C, eds.. Principles and Practice of Gynecologic Oncology. 8th ed. Philadelphia, PA: Wolters Kluwer; 2025: Kindle versoin, chapter 2.3.
  • Macmillan Cancer Support. Vulval cancer. 2021. https://www.macmillan.org.uk/.
  • Musunuru HB, Vargo JA, Olawaiye AB, Beriwal S. Cancer of the vagina and vulva. DeVita VT Jr, Lawrence TS, Rosenberg S. eds. DeVita Hellman and Rosenberg's Cancer: Principles and Practice of Oncology. 12th ed. Philadelphia, PA: Wolters Kluwer; 2023: Kindle version, chapter 49, https://read.amazon.ca/?asin=B0BG3DPT4Q&language=en-CA.
  • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Vulvar Cancer. Version 4.2024. 2024. https://www.nccn.org/home.
  • Olawaiye AB, Cuello MA, Rogers LJ. Cancer of the vulva: 2021 update. International Journal of Gynecology & Obstetrics. 2021: 155 Suppl 1(Suppl 1):7–18.
  • Olawaiye AB, Cotler J, Cuello MA, et al. FIGO staging for carcinoma of the vulva: 2021 revision. International Journal of Gynecology & Obstetrics. 2021: 155(1):43–47.

The vulva

The vulva includes the visible sex organs that surround the vaginal opening, including the clitoris and the labia.

Cancerous tumours of the vulva

Squamous cell carcinoma is the most common type of vulvar tumour. Vulvar melanoma is the second most common type.

Precancerous conditions of the vulva

Precancerous conditions of the vulva are changes to vulvar cells that make them more likely to develop into cancer.

Non-cancerous tumours and conditions of the vulva

Fibromas and lipomas are common non-cancerous tumours of the vulva. Vulvar cysts and lichen sclerosus are common non-cancerous conditions of the vulva.

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