Prognosis and survival for thymus cancer

Last medical review:

A prognosis is the doctor’s best estimate of how cancer will affect you and how it will respond to treatment. Survival is the percentage of people with a disease who are alive at some point in time after their diagnosis. Prognosis and survival depend on many factors.

Your doctor will look at certain aspects of the cancer as well as characteristics such as your age and if you have any other health problems. These are called prognostic factors. Your doctor will also look at predictive factors, which influence how a cancer will respond to a certain treatment and how likely it is that the cancer will come back after treatment.

Prognostic and predictive factors are often discussed together. They both play a part in deciding on a prognosis and a treatment plan just for you. Only a doctor familiar with your medical history, the type and stage or other features of the cancer, the treatments chosen and the response to treatment can put all of this information together with survival statistics to arrive at a prognosis and chances of survival.

The following are prognostic and predictive factors for thymus cancer.

Classification

Most thymus cancers are divided into groups using the World Health Organization (WHO) classification system. Type A, type AB and type B1 thymomas usually have a very good prognosis because the tumour cells look like normal thymus cells. Type B2 and type B3 thymomas have a less favourable prognosis because they are made up of abnormal thymus cells.

Thymic carcinomas (also called type C) usually have a poorer prognosis than thymoma because they tend to be aggressive tumours that have grown quickly and spread to other parts of the body when they are diagnosed. These cancer cells look very different from normal epithelial cells of the thymus.

Find out more about the classification of thymoma and thymic carcinoma.

Stage

Stage is an important prognostic factor for thymus cancer. Early-stage thymoma or thymic carcinoma that is only in the thymus or surrounding fat tissue has a better prognosis than later- stage cancers that have grown into nearby organs or tissues in the chest or spread to other areas of the body.

Find out more about stages of thymus cancer.

Surgery to remove the tumour

Surgery is usually used to treat thymus cancer. Thymus cancer that is completely removed by surgery has a much more favourable prognosis than thymus cancer that is not completely removed or if surgery can’t be done.

Age

People who are older than 70 have a less favourable prognosis than people younger than 70.

Expert review and references

  • Donna Maziak, MD, MSc, FRCPC
  • Girard N, Ruffini E, Marx A, Faivre-Finn C, Peters S. Thymic epithelial tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2015: Supplement 5:v40-v55.
  • Cabezon-Gutierrez L, Pacheco-Barcia V, Carrasco-Valero F, Palka-Kotlowska M, Custodio-Cabello S, Khosravi-Shahi P. Update on thymic epithelial tumors: a narrative review. Mediastinum. 2024: 8:33.
  • PDQ Adult Treatment Editorial Board. Thymoma and Thymic Carcinoma Treatment (PDQ®) – Health Professional Version. Bethesda, MD: National Cancer Institute; 2024. https://www.cancer.gov/.
  • Sorin V, Kirshenboim Z, Klug M, Ahuja J, Marom EM. The ninth edition TNM staging classification for thymic epithelial tumors. Seminars in Ultrasound CT and MRI. 2024: 45: 420-429.

Survival statistics for thymus cancer

Survival statistics for thymus cancer are very general estimates. Survival is different for each type of tumour amd each stage.

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